Journal article
An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
DJ Hare, P Lei, S Ayton, BR Roberts, R Grimm, JL George, DP Bishop, AD Beavis, SJ Donovan, G McColl, I Volitakis, CL Masters, PA Adlard, RA Cherny, AI Bush, DI Finkelstein, PA Doble
Chemical Science | ROYAL SOC CHEMISTRY | Published : 2014
DOI: 10.1039/c3sc53461h
Abstract
The co-localization of iron and dopamine raises the risk of a potentially toxic reaction. Disturbance of the balance in this unique chemical environment makes neurons in the substantia nigra pars compacta (SNc) particularly vulnerable to parkinsonian neurodegeneration in the aging brain. In Parkinson's disease, these neurons degenerate coincident with an elevation in brain iron levels, yet relatively little is known about specific regional iron distribution with respect to dopamine. To directly appraise the iron-dopamine redox couple, we applied immuno-assisted laser ablation-inductively coupled plasma-mass spectrometry imaging to co-localize iron with the dopamine-producing enzyme tyrosine ..
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Awarded by Kenelec Scientific
Funding Acknowledgements
This work was supported by funds from the Australian Research Council, Agilent Technologies and Kenelec Scientific (as part of the Linkage Projects program, LP100200254), the Australian National Health & Medical Research Council, the Cooperative Research Centre for Mental Health, the Alzheimer's Association and Operational Infrastructure Support from the Victorian State Government. So. ware was developed by Dr Michael Lake of the Computational Research Support Unit of the University of Technology, Sydney. Dr Christine Austin assisted with manuscript editing. We would like to thank Jonas Marnell of Ethix Design for assistance with digital artwork.